The reference site for Indomethacin

Indometacin (INN and BAN) or indomethacin (AAN, USAN and former BAN) is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation.

WHAT IS INDOMETHACIN?

Indomethacin is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).

This medicine is effective in reducing hormones that cause pain, inflammation, and stiffness caused by many conditions such as osteoarthritis, rheumatoid arthritis, gout, ankylosing spondylitis, tendinitis, and bursitis. It works by inhibiting the production of prostaglandins, molecules known to cause these symptoms.

It is marketed under several brand names, including Indocin®, Indocid®,Indochron E-R® and Indocin-SR®.

 

Brand Name(s): Indochron E-R; Indocin
CAS nº: 53-86-1
(in doe meth’ a sin)

Product Info

The sections below will provide you with more specific information and guidelines related to indomethacin and its correct use. Please read them carefully.

FDA Information

Indomethacin was discovered in 1963 and was first approved for use in the U.S. by the Food and Drug Administration in 1965.

Its mechanism of action, along with several other NSAIDs that inhibit COX, was described in 1971.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Indomethacin is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).

This medicine is effective in reducing hormones that cause pain, inflammation, and stiffness caused by many conditions such as osteoarthritis, rheumatoid arthritis, gout, ankylosing spondylitis, tendinitis, and bursitis. It works by inhibiting the production of prostaglandins, molecules known to cause these symptoms.

Other uses for this medicine

This medication may also be used to relieve pain caused by inflammation of the pouch surrounding the heart.

Furthermore, indomethacin has also been administered to reduce intracranial pressure (ICP) during acute liver failure (ALF).

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Indomethacin comes as a regular capsule, extended-release (long-acting) capsule, and a liquid to be taken orally, as well as suppositories to be used rectally.

Indomethacin capsules, liquid, and suppositories are usually taken two to four times a day, and extended-release capsules are taken one or two times a day.

Take indomethacin exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water, and with food, milk, or an antacid to lessen any possible stomach upset.

Do not break, crush, or chew the sustained-release formulations of indomethacin (Indocin SR®). Swallow them whole.

When using the liquid for, make sure you shake the suspension well before measuring a dose. To ensure that you get a correct dose, measure the suspension with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

On the other hand, use the suppositories rectally as directed by your doctor. If you do not know how to properly use the suppository, ask your nurse, doctor, or pharmacist for instructions. Do not take the suppositories by mouth.

What special precautions should I follow?

BEFORE TAKING INDOMETHACIN:

Please inform your doctor if you have an allergy to aspirin or any other NSAIDs, have an ulcer or bleeding in the stomach, liver or kidney disease, a coagulation (bleeding) disorder, congestive heart failure, fluid retention, heart disease, or suffer from high blood pressure. You may not be able to take indomethacin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Moreover, do not use indomethacin suppositories without first talking to your doctor if you have a history of inflammation of the rectum (proctitis) or if you have recently had rectal bleeding.

It is not known whether indomethacin taken early in pregnancy will be harmful to an unborn baby. Indomethacin must not be taken late in pregnancy (the third trimester) because it can affect the baby’s heart. Do not take indomethacin without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Furthermore, indomethacin passes into breast milk and may affect a nursing baby. Do not take indomethacin without first talking to your doctor if you are breast-feeding a baby.

Avoid prolonged exposure to sunlight. Indomethacin may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

More importantly, try to avoid alcohol or use it in moderation. If you drink more than three alcoholic beverages a day, indomethacin may increase the risk of dangerous stomach bleeding. Talk to your doctor before taking indomethacin if you drink more than 3 alcoholic beverages a day.

What should I do if I forget a dose?

If you are taking indomethacin on a regular schedule, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose.

If you are taking indomethacin as needed, take the missed dose if it is needed, then wait for the recommended or prescribed amount of time before taking another dose.

What side effects can this medication cause?

Possible side effects from indomethacin may include:

nausea
vomiting
diarrhea
stomach discomfort
heartburn
rash
headache
dizziness and drowsiness

Tell your doctor if any of these symptoms are severe or do not go away:

dizziness or headache
nausea, gaseousness, diarrhea, or constipation
depression
fatigue or weakness
dry mouth
irregular menstrual periods

If you experience any of the following symptoms, call your doctor immediately:

an allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, tongue, or face, or hives)
muscle cramps, numbness, or tingling
ulcers (open sores) in the mouth
rapid weight gain (fluid retention)
seizures
decreased hearing or ringing in the ears
yellowing of the skin and eyes (jaundice)
abdominal cramping, indigestion, or heartburn

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). The suppositories and suspension can be stored at room temperature or in the refrigerator.

Remeber to throw away any medication that is outdated or no longer needed. Should you have any questions, talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of a suspected overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services immediately on 911.

Symptoms of overdose may include:

nausea
vomiting
stomach pain
dizziness
drowsiness
headache
ringing in the ears
blurred vision
seizures
sweating
numbness or tingling
little or no urine production
slow breathing

Product Images

PICTURES OF INDOMETHACIN PILLS

Below you will find images and specific information on the principal types of indomethacin that exist, including their respective brand name(s), strength, inscription codes and manufacturers.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: INDOMETHACIN
Strength(s): 25 MG
Imprint: 4029
Manufacturer: IVAX PHARMACEUTICALS

Name: INDOMETHACIN
Strength(s): 25 MG
Imprint: MYLAN 143
Manufacturer: MYLAN

Name: INDOCIN®
Strength(s): 50 MG
Imprint: MSD 50 INDOCIN
Manufacturer: MERCK & CO.

Name: INDOMETHACIN
Strength(s): 50 MG
Imprint: 4030
Manufacturer: IVAX PHARMACEUTICALS.

Name: INDOMETHACIN
Strength(s): 50 MG
Imprint: MYLAN 147
Manufacturer: MYLAN

Name: INDOMETHACIN Suppository
Strength(s): 100 MG
Imprint: NONE
Manufacturer: BARAKAT PHARM.

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